![]() They do not contain tobacco or cannabis but when smoked, produce effects similar to those of cannabis. Typical of these were Spice Gold, Spice Silver and Yucatan Fire, but many other products later appeared. In late 2008, several cannabinoids were detected in herbal smoking mixtures or so-called incense/room odorisers. However, it proved difficult to separate the desired properties from unwanted psychoactive effects. More correctly designated as cannabinoid receptor agonists, they were initially developed over the past 40 years as therapeutic agents, often for the treatment of pain. ![]() Like THC, they bind to the same cannabinoid receptors in the brain and other organs as the endogenous ligand anandamide. Synthetic cannabinoids are functionally similar to Δ 9-tetrahydrocannabinol ( THC), the active principle of cannabis.
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